A systematic review of adults with Dravet syndrome

Dravet Syndrome (DS) is a rare and severe infantile-onset epileptic encephalopathy. DS research focuses mainly on children. We did systematic review, completed January 18th, 2021, examining the number of clinical studies. show that there are 208 studies children exclusively, 28 adults 116 involving combined. This 7:1 ratio to adult exclusively shows dearth addresses long-term natural history into adulthood.Through this we examine most up-to-date information in as it pertains seizures, electroencephalogram, imaging, treatment, motor abnormalities, cognitive social behavior outcomes, cardiac sleep disturbances, diagnosis adults, mortality.Overall, frequency seizures increases first decade life then myoclonic, atypical absences focal with impaired awareness tend decrease or even disappear adulthood. Adults have notable reduction status epilepticus, especially after 30 years age. Parkinsonian features were seen patients young 19 old more older patients, suggesting progression parkinsonian symptoms. In adulthood, continue present problems, associated lower health-related quality life. The leading reported cause death Sudden Unexpected Death Epilepsy (SUDEP).Further needed understand outcomes DS.